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The Complexity of Pain Management in Children Affected by Mucopolysaccharidoses
Sabrina Congedi1, Chiara Di Pede1,2, Maurizio Scarpa1,3
1Pediatric Pain and Palliative Care Service, Department of Women's and Children's Health, University of Padova, Via Giustiniani 3, 35128 Padova, Italy.
Abstract:
Mucopolysaccharidoses (MPSs) are a group of rare, genetic lysosomal storage disorders. They are caused by deficiencies of the lysosomal enzymes involved in the degradation of glycosaminoglycans (GAGs). Pain is a common feature in mucopolysaccharidoses. However, the pathophysiology of pain in this group of diseases is still unclear and genesis of pain is multifactorial. Currently, poor data about pain management in these patients are available. Here, we present our clinical experience in complex pain management in three children with MPS.
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