Related Experiment Video
Updated: Mar 3, 2026
06:39
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
Published on: June 13, 2025
558
Tinzaparin thromboprophylaxis prescribing practice after caesarean delivery 2009-2014
P J Maguire1, M McGuire2, K A Power2
1UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin 8, Ireland. pmaguire7@gmail.com.
Irish Journal of Medical Science
|May 6, 2017
Summary
National guidelines for tinzaparin dosing after caesarean delivery (CD) improved prescribing practices. This led to a significant reduction in venous thromboembolism (VTE) risk, with no cases of pulmonary embolism (PE) post-implementation.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Thrombosis Research
Background:
- National guidelines recommend weight-based tinzaparin dosing for caesarean delivery (CD) to prevent venous thromboembolism (VTE).
- Implementation of these guidelines aims to standardize thromboprophylaxis prescribing in maternity care.
Observation:
- This study evaluated tinzaparin usage and pulmonary embolism (PE) rates before and after guideline implementation at a university maternity hospital.
- Data on tinzaparin prescriptions and CD outcomes were collected between 2009 and 2014.
Findings:
- Following guideline adoption, the use of 4500 IU and 10,000 IU tinzaparin syringes increased significantly (P < 0.001).
- Conversely, the use of 3500 IU syringes decreased dramatically (P < 0.001).
- Two PE cases occurred between 2008-2010, both linked to inadequate tinzaparin doses; no PE cases were recorded after 9427 CDs between 2011-2014.
Implications:
- National guidelines significantly altered tinzaparin prescribing for VTE prophylaxis after CD.
- Successful implementation of weight-based dosing eliminated PE cases in the post-guideline period, highlighting the importance of adherence.
Related Concept Videos
01:29Venous Thrombosis III: Interprofessional Care
426
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
426
01:30Anticoagulant Drugs: Low-Molecular-Weight Heparins
2.1K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.1K
01:30Venous Thrombosis IV: Nursing Management
324
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
324
01:18Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants
2.6K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.6K
01:27Pulmonary Embolism III: Nursing Management
545
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
545
01:29Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care
563
Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
563