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A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro
Published on: June 2, 2022
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Calcium Balance in Chronic Kidney Disease
Kathleen M Hill Gallant1, David M Spiegel2
1Department of Nutrition Science, Purdue University, West Lafayette, IN, USA. hillgallant@purdue.edu.
Current Osteoporosis Reports
|May 6, 2017
Summary
Maintaining neutral calcium balance is crucial for patients with chronic kidney disease (CKD). Aiming for recommended daily calcium intake helps avoid risks associated with negative or positive calcium balance in CKD.
Area of Science:
- Nephrology
- Mineral Metabolism
- Bone Health
Background:
- Kidney failure disrupts calcium homeostasis and bone metabolism.
- Understanding calcium balance in chronic kidney disease (CKD) is limited.
- Both negative and positive calcium balance have significant health implications in CKD patients.
Purpose of the Study:
- To review current knowledge on calcium balance in adults with CKD.
- To discuss clinical strategies for maintaining calcium balance.
- To identify future research needs in this area.
Main Methods:
- Review of recent calcium balance studies in adult CKD patients.
- Analysis of the relationship between calcium intake and balance.
- Evaluation of clinical implications of calcium balance status.
Main Results:
- Neutral calcium balance is achievable with recommended daily calcium intake (around 1000 mg/day).
- Increased calcium intake (diet or supplements) can lead to positive calcium balance and vascular calcification risk.
- Significant heterogeneity in calcium balance exists among CKD patients.
Conclusions:
- Clinically prudent to aim for recommended calcium intakes to achieve neutral balance.
- Avoidance of negative or positive calcium balance is essential in CKD.
- Individualized recommendations based on dietary calcium assessment are needed.
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