Related Experiment Video

Updated: Mar 3, 2026

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices
02:14

Underwater Endoscopic Injection Sclerotherapy for Gastroesophageal Varices

Published on: August 1, 2025

1.8K

Cure with ledipasvir/sofosbuvir for chronic hepatitis C virus in an individual with gastric bypass

S W Johnson1,2, A L Teachey1, S M Valanejad2

  • 1Department of Pharmacy, Novant Health Forsyth Medical Center, Winston-Salem, NC, USA.

Journal of Clinical Pharmacy and Therapeutics
|May 6, 2017
PubMed

Insights

Ledipasvir/sofosbuvir (LDV/SOF) effectively cured chronic hepatitis C in a patient with a history of gastric bypass surgery. This suggests LDV/SOF may be a viable treatment option for such patients.

Area of Science:

  • Hepatology
  • Gastroenterology
  • Pharmacokinetics

Background:

  • Gastric bypass surgery alters medication pharmacokinetics.
  • Limited data exist on ledipasvir/sofosbuvir (LDV/SOF) treatment in patients with prior gastric bypass.

Observation:

  • A case report details a patient with a history of gastric bypass who underwent treatment for chronic hepatitis C.
  • The patient received LDV/SOF and experienced a successful cure.
  • Treatment was well-tolerated, with only a minor headache reported.

Findings:

  • Ledipasvir/sofosbuvir (LDV/SOF) achieved a sustained virologic response in a patient with a history of gastric bypass.
  • The patient tolerated the medication regimen without significant adverse events.

Implications:

  • Ledipasvir/sofosbuvir treatment appears effective and safe in patients with a history of gastric bypass.
  • These findings support the use of LDV/SOF in this specific patient population.
  • Further research may be warranted to confirm efficacy and safety in a larger cohort.
Abstract

Keywords:
LDV/SOFharvonihepatitis C virusledipasvir/sofosbuvir

More Related Videos

Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection06:00

Laparoscopic Anatomic S7+S8d Resection Preserving Inferior Right Hepatic Vein and S6 with Right Hepatic Vein Transection

Published on: December 30, 2025

419
Roux-en-Y Gastric Bypass Operation in Rats07:37

Roux-en-Y Gastric Bypass Operation in Rats

Published on: June 11, 2012

24.4K

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
440
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
808
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.5K
Gallbladder01:17

Gallbladder

The gallbladder is a small, pear-shaped organ that plays a crucial role in our digestive system. Measuring about 10 cm in length, it is comparable in size to a kiwi fruit and is located in a hollow area on the lower surface of the liver. The gallbladder's primary function is to store and concentrate bile, a fluid produced by the liver that aids in digestion.
The gallbladder's anatomy consists of three regions: the fundus, body, and neck. Extending from the neck, the cystic duct joins...
2.6K
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
577