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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Etodolac and the risk of acute pancreatitis
Kuan-Fu Liao1, Kao-Chi Cheng2, Cheng-Li Lin3
1College of Medicine, Tzu Chi University, Hualien 970, Taiwan - Department of Internal Medicine, Taichung Tzu Chi General Hospital, Taichung 427, Taiwan - Graduate Institute of Integrated Medicine, China Medical University, Taichung 404, Taiwan.
Objective:
The aim of this study was to explore the association between etodolac use and acute in Taiwan.
Design:
We designed a case-control study using the database of Taiwan's National Health Insurance.
Subjects:
In all, 7577 subjects aged 20 years or older with newly diagnosed acute pancreatitis were defined as cases, and 27032 sex-matched and age-matched subjects without acute pancreatitis were defined as controls. The period considered for this study was from 1998 to 2011. For the study, never having used etodolac is defined as a subject never receiving a prescription for etodolac. Active use of etodolac is defined as a subject receiving at least 1 prescription for etodolac within 7 days of the date of their being diagnosed with acute pancreatitis. Non-active use of etodolac is defined as a subject not receiving a prescription for etodolac within 7 days but receiving at least 1 prescription for etodolac ≥ 8 days before the date of their being diagnosed with acute pancreatitis.
Main Outcome Measure:
The association between etodolac use and acute pancreatitis was estimated by using the multivariable unconditional logistic regression model.
Results:
After correcting for covariates, the adjusted odds ratio of acute pancreatitis was 3.78 for subjects with active use of etodolac (95% confidence interval 1.11, 12.9), compared with subjects who never used etodolac. The adjusted odds ratio decreased to 1.18 for subjects with non-active use of etodolac (95% confidence interval 0.38, 3.67), but that was without statistical significance.
Conclusion:
There could be an association between active use of etodolac and acute pancreatitis. Clinicians should take into account the possibility of etodolac-associated acute pancreatitis when patients currently using etodolac present with acute pancreatitis with an unknown cause.
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