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Expression of the receptor for advanced glycation end products in acquired reactive perforating collagenosis

Gulsen Akoglu1, Nuran Sungu2, Eda Karaismailoglu3

  • 1Department of Dermatovenereology, Ataturk Training and Research Hospital, Ankara, Turkey.

Indian Journal of Dermatology, Venereology and Leprology
|May 6, 2017
PubMed
Abstract

Insights

Acquired reactive perforating collagenosis (ARPC) shows increased expression of the receptor for advanced glycation end products (RAGE). This RAGE overexpression in ARPC skin lesions is independent of diabetes status.

Area of Science:

  • Dermatology
  • Pathology
  • Immunohistochemistry

Background:

  • Acquired reactive perforating collagenosis (ARPC) is a rare skin condition involving collagen elimination.
  • The pathogenesis of ARPC is not well understood.
  • The receptor for advanced glycation end products (RAGE) is implicated in inflammatory processes.

Purpose of the Study:

  • To investigate the expression levels of RAGE in patients with ARPC.
  • To determine if RAGE expression differs between ARPC patients and healthy controls.

Main Methods:

  • Immunohistochemical staining for RAGE was performed on skin biopsy specimens from 41 ARPC patients and 11 healthy controls.
  • RAGE expression intensity was semi-quantitatively assessed in epidermal cells, microvascular endothelium, dermal fibroblasts, and inflammatory cells.
  • Patients were analyzed based on diabetic and non-diabetic status.

Main Results:

  • RAGE expression was significantly more intense in the microvascular endothelium and inflammatory cells of ARPC patients compared to controls (p=0.005 and p=0.017, respectively).
  • Increased RAGE expression was also observed in dermal fibroblasts, though not statistically significant (p > 0.05).

Conclusions:

  • The study observed an overexpression of RAGE in lesional samples from ARPC patients.
  • This RAGE overexpression in ARPC is independent of the presence of diabetes.

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