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Updated: Mar 3, 2026
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
[Risk factors associated to diffuse gastric cancer and intestinal histological patterns in an adult population from
Netzahualpilli Delgado-Figueroa1, Paloma Casas-Junco1, Juan Heriberto Torres-Jasso2
1División de Genética, Centro de Investigación Biomédica de Occidente, IMSS, Guadalajara, Jal., México.
Introduction:
Gastric cancer (GC) is the third leading cause of cancer death worldwide, and is divided histologically in diffuse gastric cancer (DGC) and intestinal gastric cancer (IGC). Multiple risk factors have been associated with GC in different populations. The objective was to analyze the risk factors associated to DGC and IGC in a population from the western region of Mexico.
Material And Methods:
The DGC (n = 27) and IGC (n = 26) cases, each matched by age and sex with a control group, were analyzed. Diet and lifestyle data were obtained by a questionnaire. Statistical analysis was performed with the software SPSSv18. The association of risk was calculated in odds ratio (OR); a value of p < 0.05 was considered significant.
Results:
In the DGC group, the factors with significant OR values were: consumption of pork OR: 3.4 (1.11-10.4; p =0.032), smoking OR: 4.7 (1.5-15.0; p =0.007), green vegetables OR: 0.16 (0.03-0.83; p =0.029) and fruit OR: 0.28 (0.08-0.88; p =0.029). In the IGC group, the consumption of canned sardines was a significant risk factor OR: 4.07 (1.25-13.24; p =0.019).
Conclusions:
This work is the first to analyze the risk factors associated with GC in a population from western Mexico.
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