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Updated: Mar 3, 2026
Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
Gram-Scale Synthesis of Hydrophilic PEI-Coated AgInS2 Quantum Dots and Its Application in Hydrogen Peroxide/Glucose
Lan Wang1,2, Xiaojiao Kang1, Daocheng Pan1
1State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , 5625 Renmin Road, Changchun, Jilin 130022, P. R. China.
Abstract:
Assisted with polyethylenimine, 4.0 L of water-soluble AgInS2 quantum dots (AIS QDs) were successfully synthesized in an electric pressure cooker. As-prepared QDs exhibit yellow emission with a photoluminescence (PL) quantum yield up to 32%. The QDs also show excellent water/buffer stability. The highly luminescent AIS QDs are used to explore their dual-functional behavior: detection of hydrogen peroxide (H2O2)/glucose and cell imaging. The amino-functionalized AIS QDs show high sensitivity and specificity for H2O2 and glucose with detection limits of 0.42 and 0.90 μM, respectively. A linear correlation was established between PL intensity and concentration of H2O2 in the ranges of 0.5-10 μM and 10-300 μM, while the linear ranges were 1-10 μM and 10-1000 μM for detection of glucose. The AIS QDs reveal negligible cytotoxicity on HeLa cells. Furthermore, the luminescence of AIS QDs gives the function of optical imaging.
