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Self-assembled DNA nanocentipedes as multivalent vehicles for enhanced delivery of CpG oligonucleotides
Wenshan Li1, Lei Luo, Jin Huang
1State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Key Laboratory for Bio-Nanotechnology and Molecular Engineering of Hunan Province, Hunan University, Changsha 410082, China. yangxiaohai@hnu.edu.cn kmwang@hnu.edu.cn.
Chemical Communications (Cambridge, England)
|May 6, 2017
Abstract:
We report self-assembled nanocentipedes as multivalent vehicles for the delivery of immunostimulatory CpG ODNs. The multivalent vehicles could be internalized by RAW264.7 cells and stimulate the secretion of large amounts of cytokines, successively inducing effective apoptosis of cancer cells.
