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Related Concept Videos

The Replisome03:01

The Replisome

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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
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Chromosome Replication02:31

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Before a cell can divide, it must accurately replicate all of its chromosomes, including the DNA and its associated histone and non-histone proteins.  This process begins at numerous origins of replication during the S phase of the cell cycle in each of a cell’s chromosomes simultaneously. Certain nucleotides can act as origins of replication, but these sequences are not well defined - especially in complex, multi-cellular, eukaryotic species. The length of DNA that spans an origin...
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DNA Replication02:40

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DNA replication involves the separation of the two strands of the double helix, with each strand serving as a template from which the new complementary strand is copied.  After replication, each double-stranded DNA includes one parental or “old” strand and one “new” strand. This is known as semiconservative replication. The resulting DNA molecules have the same sequence and are divided equally into the two daughter cells.
Replication in Prokaryotes
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S-Cdk Initiates DNA Replication02:38

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The cell cycle is a series of events leading to DNA duplication followed by the division of cell content to form two daughter cells. The cell cycle progresses in four stages—the cell increases in size (gap 1 or G1-phase), duplicates its DNA (synthesis or S-phase), prepares to divide (gap 2 or G2-phase), and divides (mitosis or M-phase).
Two states at the origin of replication
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Replication in Eukaryotes02:31

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Overview
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Replication in Eukaryotes01:29

Replication in Eukaryotes

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In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
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Related Experiment Video

Updated: Mar 3, 2026

Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method
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Strand-Specific Analysis of Proteins at Replicating DNA Strands by Enrichment and Sequencing of Protein-Associated Nascent DNA Method

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VII. REPLICATION, RESEARCH ACCUMULATION, AND META-ANALYSIS IN DEVELOPMENTAL SCIENCE.

Noel A Card

    Monographs of the Society for Research in Child Development
    |May 6, 2017
    PubMed
    Summary

    Replication and research accumulation are crucial for scientific progress. Focusing on effect sizes and meta-analysis enhances developmental science efficiency and precision.

    Area of Science:

    • Developmental Science
    • Research Methodology

    Background:

    • Scientific progress relies on replicating research and accumulating knowledge.
    • Developmental science often prioritizes individual studies over replication and synthesis.
    • Barriers and potentials for replication and accumulation exist within developmental science.

    Purpose of the Study:

    • To describe concepts of replication and research accumulation in developmental science.
    • To explore barriers and potentials for these processes.
    • To advocate for a shift towards accumulation-focused advancement.

    Main Methods:

    • Conceptual analysis of replication and research accumulation.
    • Emphasis on effect sizes over statistical significance.
    • Introduction of meta-analysis as a tool for synthesis and guiding replication.

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    Main Results:

    • Replication and accumulation are vital for robust scientific knowledge.
    • Effect sizes are more informative than statistical significance for accumulation.
    • Meta-analysis facilitates synthesis and directs replication efforts effectively.

    Conclusions:

    • Advancing developmental science requires prioritizing research accumulation.
    • This approach enhances efficiency and precision in guiding future research and applications.
    • A focus on accumulation, supported by meta-analysis, strengthens the field.