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Author Spotlight: Multimodal Imaging Strategies for Optimizing Drug Delivery and Early Detection in Glioblastoma Treatment

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Developing an Algorithm for Optimizing Care of Elderly Patients With Glioblastoma.

Patrick M Flanigan¹, Arman Jahangiri¹, Ruby Kuang¹

¹Department of Neurological Surgery, University of California, San Francisco, California.

|May 6, 2017

Summary

Elderly glioblastoma patients face poorer outcomes and often receive less aggressive treatment. A predictive algorithm can help identify elderly patients unlikely to benefit from aggressive resection, guiding personalized care.

Keywords:

Biopsy Comorbidity Elderly Glioblastoma Oncology Prognosis Survival

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A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells

A Rapid Screening Workflow to Identify Potential Combination Therapy for GBM using Patient-Derived Glioma Stem Cells

Published on: March 28, 2021

Area of Science:

Neuro-oncology
Geriatric Medicine
Surgical Oncology

Background:

Elderly patients with glioblastoma (GBM) have a significantly worse prognosis.
Optimizing medical and surgical management for this demographic is crucial.

Purpose of the Study:

To compare patient and treatment characteristics between elderly and non-elderly GBM patients.
To develop a predictive algorithm for survival in elderly GBM patients.

Main Methods:

Retrospective analysis of 554 GBM patients (2005-2011).
Comparison of elderly (≥65 years) versus non-elderly patients.
Development of a multivariate predictive model for elderly patient survival based on preoperative factors.

Main Results:

Elderly patients were more likely to undergo biopsy only, have comorbidities, and experience post-resection morbidity.
Elderly patients received less gross total resection and temozolomide (TMZ).
A predictive algorithm identified elderly patients with 6-9 points (based on age, comorbidities, tumor size, and resection extent) who had survival rates similar to those undergoing biopsy only.

Conclusions:

Personalized treatment strategies are essential for elderly GBM patients.
Avoiding aggressive resection in elderly patients unlikely to benefit may improve outcomes.
Further research into optimizing care for elderly GBM patients is warranted.