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Sweat gland carcinoma ex eccrine spiradenoma
M R Wick1, P E Swanson, V N Kaye
1Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine, Minneapolis.
The American Journal of Dermatopathology
|April 1, 1987
Summary
We report two cases of sweat gland carcinoma developing from eccrine spiradenoma. This rare cancer can metastasize rapidly, highlighting the need for early diagnosis and treatment.
Area of Science:
- Dermatopathology
- Oncology
Background:
- Eccrine spiradenoma is a benign sweat gland tumor.
- Malignant transformation of eccrine spiradenoma into sweat gland carcinoma is rare.
Observation:
- Two cases of sweat gland carcinoma arising in association with eccrine spiradenoma are presented.
- Lesions appeared as enlarging masses after years of stability.
- One case showed rapid, widespread metastasis and was fatal within 5 months.
Findings:
- Immunohistochemistry revealed an antigenic link between benign and malignant components.
- Ultrastructural analysis indicated limited specialized differentiation in the malignant cells.
- This neoplasm exhibits variable microscopic features.
Implications:
- Sweat gland carcinoma ex eccrine spiradenoma is an aggressive malignancy.
- The 20% fatality rate underscores the seriousness of this condition.
- Further research into the pathogenesis and behavior of these tumors is warranted.