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Related Concept Videos

Pinocytosis00:38

Pinocytosis

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Cells use energy-requiring bulk transport mechanisms to transfer large particles or large numbers of small particles into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
Pinocytosis ("cellular drinking") is one of three main types of...
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Pinocytosis00:43

Pinocytosis

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Cells use energy-requiring bulk transport mechanisms to transfer large particles, or large amounts of small particles, into or out of the cell. The cells envelop the particles in spherical membranes called vesicles or vacuoles. Vesicles that transport material into the cell are built from the cell membrane. These vesicles encapsulate external molecules and transport them into the cell in a process called endocytosis.
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Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells,...
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Phagocytosis00:41

Phagocytosis

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Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
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Pinching-off of Coated Vesicles01:32

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Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
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Delivery Pathways to the Lysosome01:36

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Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
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Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes
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Automated Imaging and Analysis for the Quantification of Fluorescently Labeled Macropinosomes

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SnapShot:Macropinocytosis.

Pedro E Marques1, Sergio Grinstein2, Spencer A Freeman1

  • 1Program in Cell Biology, Peter Gilgan Centre for Research and Learning, Hospital for Sick Children, 686 Bay Street, 19-9800, Toronto, ON M5G 0A4, Canada.

Cell
|May 6, 2017
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Summary
This summary is machine-generated.

Macropinocytosis, the cell’s bulk fluid uptake, is vital for immune surveillance. This process also contributes to infection and cancer progression.

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Area of Science:

  • Cell Biology
  • Immunology
  • Pathology

Background:

  • Macropinocytosis is a cellular process involving the bulk uptake of extracellular fluid through large endocytic vacuoles.
  • This mechanism plays a crucial role in various physiological processes, including immune cell function.

Purpose of the Study:

  • To provide an overview of the physiological roles of macropinocytosis.
  • To explore the pathogenic contributions of macropinocytosis in disease states.

Main Methods:

  • Literature review of macropinocytosis.
  • Analysis of macropinocytosis in immune surveillance.
  • Investigation of macropinocytosis in infection and cancer.

Main Results:

  • Macropinocytosis is essential for immune surveillance by antigen-presenting cells.
  • Aberrant macropinocytosis is implicated in the proliferation and survival of cancer cells.
  • Macropinocytosis can be exploited by pathogens to facilitate infection.

Conclusions:

  • Macropinocytosis is a fundamental cellular process with dual roles in health and disease.
  • Understanding macropinocytosis offers potential therapeutic targets for infections and cancer.