Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

1.1K
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
1.1K
Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones01:24

Acetals and Thioacetals as Protecting Groups for Aldehydes and Ketones

6.0K
Acetals are formed by reacting two equivalents of alcohol with carbonyl compounds like aldehydes or ketones. Acetals are unaffected by bases, nucleophiles, oxidizing agents, and reducing agents. They serve as protecting groups for aldehydes and ketones. Acetals can be easily formed and also easily removed via mild acid hydrolysis.
In the presence of multiple functional groups, when selective reduction of one group over the other is desired, groups like aldehydes and ketones that form acetals...
6.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A stochastic block prior for clustering in graphical models.

Psychological methods·2026
Same author

Progressive reduction in complications of cryoballoon pulmonary vein isolation for atrial fibrillation.

Journal of cardiovascular medicine (Hagerstown, Md.)·2026
Same author

Design and Characterization of a Bioinspired PAMAM@Poly(Caffeic Acid) Magnetite Nanocarrier for Curcumin Delivery.

ACS omega·2026
Same author

HMC3 revealed: how much do these "Microglia" really tell us?

Frontiers in immunology·2026
Same author

PARP1 rewires neuroinflammatory and redox metabolism associated with reactive neuroglia in neuropathic pain.

Redox biology·2026
Same author

Memantine prevents acute stress-induced memory deficits by reversing sex-dependent pathophysiological glutamatergic alterations in the dorsal hippocampus.

British journal of pharmacology·2026
Same journal

Fully synthetic arecoline and arecaidine vaccine candidates with α-Galactosylceramide as built-in adjuvant.

European journal of medicinal chemistry·2026
Same journal

GPR120/free fatty acid receptor 4 (FFAR-4) agonists, antagonists, allosteric modulators: Computational drug design and discovery review.

European journal of medicinal chemistry·2026
Same journal

The development of novel ferrocenyl quinoline-benzimidazole molecular hybrids against cutaneous leishmaniasis.

European journal of medicinal chemistry·2026
Same journal

2-Pyridone as privileged scaffold: Advances in drug design and structural modification.

European journal of medicinal chemistry·2026
Same journal

Application of glycoconjugated metal complexes in cancer therapy.

European journal of medicinal chemistry·2026
Same journal

Enabling lead optimization with a focus on optimal dose selection by utilizing multi-parametric data visualization techniques.

European journal of medicinal chemistry·2026
See all related articles

Related Experiment Video

Updated: Mar 3, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
06:17

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

12.7K

Multitarget trehalose-carnosine conjugates inhibit Aβ aggregation, tune copper(II) activity and decrease acrolein

Giuseppa Ida Grasso1, Francesco Bellia1, Giuseppe Arena2

  • 1Institute of Biostructure and Bioimaging, National Research Council (CNR), via P. Gaifami 18, 95126, Catania, Italy.

European Journal of Medicinal Chemistry
|May 6, 2017
PubMed
Summary
This summary is machine-generated.

This study explores new trehalose-carnosine bio-conjugates as multi-functional agents to combat neurodegenerative disorders by reducing amyloid aggregation and oxidative stress from acrolein.

Keywords:
Antiglycating effectAβ aggregationCarnosineCopper complexesTrehalose

More Related Videos

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

10.1K
Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
06:23

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

Published on: October 30, 2018

8.6K

Related Experiment Videos

Last Updated: Mar 3, 2026

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
06:17

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis

Published on: May 22, 2018

12.7K
Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

10.1K
Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
06:23

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons

Published on: October 30, 2018

8.6K

Area of Science:

  • Neuroscience
  • Biochemistry
  • Materials Science

Background:

  • Neurodegenerative disorders are linked to amyloid aggregates, metal ion imbalance, and oxidative stress.
  • Acrolein, a biological oxidation product, plays a significant role in neurodegeneration.
  • Multi-functional biomolecules offer a promising therapeutic strategy.

Purpose of the Study:

  • To investigate novel trehalose-carnosine bio-conjugates for treating neurodegenerative diseases.
  • To evaluate the antiaggregating, antioxidant, and antiglycating properties of these conjugates.
  • To assess their capacity to sequester acrolein and inhibit protein aggregation.

Main Methods:

  • Synthesis of a new trehalose-carnosine conjugate.
  • Assessment of antiaggregating properties against self- and metal-induced aggregation.
  • Evaluation of antioxidant effects and acrolein sequestration capabilities.
  • Investigation of copper(II) coordination properties.

Main Results:

  • The trehalose-carnosine conjugate demonstrated significant antiaggregating and antioxidant activities.
  • The conjugate effectively sequestered acrolein, mitigating its toxicity.
  • Copper(II) coordination properties were characterized, revealing potential therapeutic mechanisms.

Conclusions:

  • Trehalose-carnosine bio-conjugates represent a promising therapeutic approach for neurodegenerative disorders.
  • These multi-functional molecules address key pathological hallmarks including aggregation and oxidative stress.
  • Further research into these conjugates could lead to novel treatments for brain diseases.