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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Catenins01:23

Catenins

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
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Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Related Experiment Video

Updated: Mar 3, 2026

The Soft Agar Colony Formation Assay
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Wnt/beta-catenin pathway: modulating anticancer immune response.

Sachin Gopalkrishna Pai1,2,3, Benedito A Carneiro4,5, Jose Mauricio Mota6

  • 1Developmental Therapeutics Program, Division of Hematology/Oncology, Feinberg School of Medicine, Chicago, IL, USA. spai@health.southalabama.edu.

Journal of Hematology & Oncology
|May 7, 2017
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The Wnt/β-catenin pathway regulates cell functions and is crucial in cancer development. Targeting this pathway offers new therapeutic strategies, including enhancing immunotherapy responses.

Keywords:
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Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • The Wnt/β-catenin signaling pathway is evolutionarily conserved and controls fundamental cellular processes like proliferation, differentiation, and stem cell renewal.
  • Aberrations in the Wnt/β-catenin pathway are implicated in various cancers, making it a key target for therapeutic interventions.
  • Recent findings highlight the pathway's role in modulating the tumor microenvironment and influencing immunotherapy effectiveness.

Purpose of the Study:

  • To review the critical role of the Wnt/β-catenin pathway in cancer biology.
  • To discuss current and emerging therapeutic strategies targeting the Wnt/β-catenin pathway.
  • To explore the pathway's impact on the tumor immune microenvironment and its implications for cancer immunotherapy.

Main Methods:

  • Literature review of Wnt/β-catenin signaling in cancer.
  • Analysis of WNT-directed therapeutic approaches.
  • Examination of the pathway's interaction with the tumor microenvironment and immunotherapy.

Main Results:

  • The Wnt/β-catenin pathway is frequently dysregulated in cancer, driving tumor growth and progression.
  • Targeting Wnt/β-catenin signaling is a promising strategy for cancer treatment.
  • Modulation of this pathway can impact immune cell infiltration and response to immunotherapy.

Conclusions:

  • The Wnt/β-catenin pathway is a significant player in cancer pathogenesis and a viable therapeutic target.
  • Understanding its role in the tumor microenvironment is crucial for optimizing cancer immunotherapy.
  • Further research into WNT-directed therapies holds potential for improved cancer treatment outcomes.