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Defining the role of the RSK isoforms in cancer

Thibault Houles1, Philippe P Roux2

  • 1Institute for Research in Immunology and Cancer (IRIC), Canada.

Seminars in Cancer Biology
|May 7, 2017
PubMed

Insights

The 90kDa ribosomal S6 kinase (RSK) family, crucial for cell growth, is implicated in various cancers. Targeting RSK offers therapeutic potential, but isoform-specific inhibitors are needed.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Oncology

Background:

  • The 90kDa ribosomal S6 kinase (RSK) family comprises Ser/Thr protein kinases (RSK1-4) functioning downstream of the Ras/MAPK pathway.
  • RSK regulates key cellular processes including survival, growth, and proliferation.
  • Dysregulated RSK activity is linked to the development and progression of multiple cancer types, such as breast, prostate, and lung cancer.

Purpose of the Study:

  • To review current knowledge on RSK activation and function.
  • To highlight RSK-dependent mechanisms in tumorigenesis.
  • To discuss the potential and challenges of pharmacological RSK inhibition for cancer therapy.

Main Methods:

  • Literature review of RSK signaling pathways.
  • Analysis of studies linking RSK to cancer development.
  • Examination of current and emerging RSK inhibitors.

Main Results:

  • RSK plays a significant role in promoting cancer cell survival, growth, and proliferation.
  • Aberrant RSK expression and activity are observed across various malignancies.
  • RSK is identified as a promising therapeutic target in oncology.

Conclusions:

  • Targeting RSK signaling presents a viable strategy for cancer treatment.
  • Development of RSK inhibitors with improved pharmacokinetics and isoform selectivity is crucial.
  • Further research into RSK-dependent tumorigenesis mechanisms will guide therapeutic development.
Keywords:
Cell signallingMAPKPhosphorylationProliferationProtein kinaseRSK, cancer

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