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Related Experiment Videos

An hypothesis for high multiple pregnancies after clomiphene.

D L Healy, H G Burger

    The Australian & New Zealand Journal of Obstetrics & Gynaecology
    |November 1, 1978
    PubMed
    Summary

    Clomiphene ovulation induction can lead to multiple pregnancies, including triplets and quadruplets. Increasing dosage or adding human chorionic gonadotropin (HCG) enhanced follicle development, resulting in multiple ovulations.

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    Pregnancies conceived using assisted reproductive technologies (ART) have low levels of pregnancy-associated plasma protein-A (PAPP-A) leading to a high rate of false-positive results in first trimester screening for Down syndrome.

    Human reproduction (Oxford, England)·2009

    Area of Science:

    • Reproductive endocrinology
    • Human reproduction
    • Obstetrics and Gynecology

    Background:

    • Secondary amenorrhea and anovulatory cycles can follow oral contraceptive use.
    • Initial clomiphene therapy may result in suboptimal ovarian stimulation.
    • Multiple pregnancies are a known risk of ovulation induction therapies.