Related Experiment Video

Updated: Mar 3, 2026

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

6.5K

IFNγ Acts on Endothelial Cells to Promote Tumor Regression

    Cancer Discovery
    |May 7, 2017
    PubMed

    Insights

    Interferon gamma (IFNγ) triggers blood vessel breakdown and tumor starvation, leading to tumor shrinkage. This discovery offers new insights into cancer therapy strategies.

    Area of Science:

    • Immunology
    • Oncology
    • Vascular Biology

    Background:

    • Tumor growth relies on neovasculature.
    • Interferon gamma (IFNγ) is a key cytokine in immune responses.
    • Targeting tumor vasculature is a therapeutic strategy.

    Purpose of the Study:

    • To investigate the role of IFNγ in tumor vascular regression.
    • To elucidate the mechanisms by which IFNγ induces tumor ischemia.

    Main Methods:

    • In vivo tumor models were utilized.
    • Vascular integrity and blood flow were assessed.
    • Tumor regression was monitored.

    Main Results:

    • IFNγ administration led to significant vascular regression within tumors.
    • Tumor ischemia was observed following IFNγ treatment.
    • IFNγ treatment initiated and promoted tumor regression.

    Conclusions:

    • IFNγ is a potent inducer of tumor vascular regression and ischemia.
    • Targeting tumor vasculature with IFNγ presents a promising therapeutic approach for cancer treatment.

    More Related Videos

    Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses10:10

    Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses

    Published on: November 16, 2016

    14.4K
    In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research08:53

    In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

    Published on: September 16, 2019

    9.7K

    Related Concept Videos

    Regulation of Angiogenesis and Blood Supply01:24

    Regulation of Angiogenesis and Blood Supply

    Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
    3.8K
    Tumor Immunotherapy01:27

    Tumor Immunotherapy

    Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
    2.1K
    The Tumor Microenvironment02:17

    The Tumor Microenvironment

    Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
    8.0K
    Cells of the Innate Immune Response01:28

    Cells of the Innate Immune Response

    The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
    Phagocytes
    Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
    9.8K
    Intracellular Signaling Affects Focal Adhesions01:17

    Intracellular Signaling Affects Focal Adhesions

    Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
    Some...
    3.7K
    Mitogens and the Cell Cycle02:38

    Mitogens and the Cell Cycle

    Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
    8.2K