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Pharmacogenetic Approach to Toxicity in Breast Cancer Patients Treated with Taxanes

Silvia Angelini1,2, Andrea Botticelli1, Concetta Elisa Onesti3,2

  • 1Department of Clinical and Molecular Medicine, "Sapienza" University of Rome, Rome, Italy.

Anticancer Research
|May 7, 2017
PubMed
Abstract

Insights

Single-nucleotide polymorphisms in ABCB1 may influence taxane chemotherapy toxicity in breast cancer patients. The ABCB1 3435 T/T genotype is associated with reduced toxicity, suggesting a potential biomarker for personalized treatment.

Area of Science:

  • Pharmacogenomics
  • Oncology
  • Molecular Biology

Background:

  • Taxanes are crucial in breast cancer chemotherapy.
  • Their metabolism involves cytochrome CYP3A and ABCB1 transporters.
  • Genetic variations (SNPs) in these genes may explain treatment toxicity differences.

Purpose of the Study:

  • To investigate the association between specific gene polymorphisms and taxane-induced toxicity in breast cancer patients.
  • To explore the role of CYP3A4, CYP3A5, and ABCB1 gene variants in treatment response.

Main Methods:

  • Retrospective analysis of 152 breast cancer patients undergoing taxane chemotherapy.
  • Genotyping performed for CYP3A4*1B, CYP3A5*3, and ABCB1 (C1236T, C3435T) polymorphisms.
  • Correlation analysis between genotypes and observed toxicities.

Main Results:

  • A statistically significant association was found between the ABCB1 3435 T/T genotype and lower-grade toxicities (p=0.05).
  • No significant associations were observed for CYP3A4*1B, CYP3A5*3, or the ABCB1 C1236T polymorphism.
  • The ABCB1 3435 T/T genotype appears linked to reduced taxane toxicity.

Conclusions:

  • The ABCB1 3435 T/T genotype may predict a lower incidence of toxicity in patients treated with taxanes.
  • Further large-scale prospective studies are warranted to confirm these findings.
  • This polymorphism could potentially guide personalized chemotherapy strategies.
Keywords:
ABCB1Breast cancerP-gpcytochrome P450polymorphismstaxanes

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