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The role of miR-130a in cancer

He-da Zhang1,2, Lin-Hong Jiang3, Da-Wei Sun4

  • 1Department of General Surgery, Southeast University Medical School, 87 Ding Jia Qiao, Nanjing, 210009, Jiangsu, China.

Breast Cancer (Tokyo, Japan)
|May 7, 2017
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are crucial in cancer development. This review highlights miR-130a

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are short, non-coding RNA molecules regulating gene expression post-transcriptionally.
  • miRNAs are implicated in crucial cellular processes like growth, apoptosis, metastasis, and drug resistance.
  • The miR-130 family, including miR-130a and miR-130b, plays roles in various cancers.

Purpose of the Study:

  • To review the function of miR-130a in cancer pathogenesis.
  • To specifically elucidate the role of miR-130a in cancer drug resistance.
  • To identify miR-130a as a potential therapeutic target for cancer treatment.

Main Methods:

  • Literature review of studies on miR-130a and cancer.
  • Analysis of miR-130a's involvement in key signaling pathways related to drug resistance.
  • Synthesis of evidence linking miR-130a to chemoresistance in various cancer types.

Main Results:

  • miR-130a is implicated in the pathogenesis of multiple cancers, including hepatocellular carcinoma, leukemia, and glioblastoma.
  • miR-130a acts as a mediator in drug resistance signaling pathways such as PI3K/Akt/PTEN/mTOR, Wnt/β-catenin, and NF-kB/PTEN.
  • Evidence strongly associates miR-130a with acquired resistance to chemotherapy.

Conclusions:

  • miR-130a is a significant factor in cancer development and progression.
  • miR-130a's role in mediating drug resistance presents it as a promising therapeutic target.
  • Targeting miR-130a may offer novel strategies to overcome chemotherapy resistance in cancer patients.
Keywords:
CancerDrug resistanceMiR-130aMicroRNA

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