Related Experiment Videos
Cyclic AMP as an inducer of the cell differentiation of Trypanosoma cruzi
R Rangel-Aldao1, F Triana, V Fernández
1Centro de Investigaciones Biomédicas, Universidad de Carabobo, Venezuela.
Biochemistry International
|August 1, 1988
Abstract:
The addition to epimastigotes cultures of T. cruzi, of either cAMP, monobutyryl-cAMP, dibutyryl-cAMP, 8-Br-cAMP (at 2 mM each), or the cAMP-phosphodiesterase inhibitor, papaverine (0.2 mM), promoted the in vitro differentiation of these parasite forms into metacyclics. This effect of cAMP may also be exerted in vivo in the insect vector, since cAMP was detected in the urine and in the Malpighi secretion fluids of Rodnius prolixus.