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What keeps children with cystic fibrosis awake at night?

Moya Vandeleur1, Lisa M Walter2, David S Armstrong3

  • 1The Ritchie Centre, Department of Paediatrics, Monash University and Hudson Institute of Medical Research, Monash Medical Centre, 246 Clayton Road, Melbourne, Victoria 3168, Australia; Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia.

Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society
|May 9, 2017
PubMed

Insights

Poor sleep quality in children with cystic fibrosis (CF) is linked to lung health, co-morbidities, family factors, and electronic device use. Improving CF management and sleep hygiene can enhance sleep in affected children.

Area of Science:

  • Pediatric Pulmonology
  • Sleep Medicine
  • Cystic Fibrosis Research

Background:

  • Sleep disturbance is prevalent in children with cystic fibrosis (CF).
  • Limited research has explored the specific causes of poor sleep quality in this population.
  • This study aimed to identify clinical factors associated with sleep disturbance in children with CF.

Purpose of the Study:

  • To evaluate the clinical correlates of sleep disturbance in children with cystic fibrosis.
  • To identify factors contributing to poor sleep quantity and quality.
  • To explore the relationship between lung health, comorbidities, and sleep in pediatric CF patients.

Main Methods:

  • Cross-sectional observational study involving children with CF aged 7-18 years.
  • Participants were free from pulmonary exacerbation during the study period.
  • Data collected included medical review, overnight oximetry, OSA-18 questionnaire, 14-day actigraphy, and sleep diary.

Main Results:

  • Reduced lung function (FEV1 <80%), low baseline SpO2, CF-related diabetes, PEG feeding, and behavioral disorders were associated with lower objective sleep quantity.
  • Paternal smoking, family history of mood disorders, and pre-bedtime electronic device use correlated with poorer sleep quantity and quality.
  • FEV1, nocturnal cough, age, and behavioral disorders predicted sleep duration; FEV1, nocturnal cough, SpO2 nadir, and asthma predicted sleep efficiency. Sleep efficiency also independently predicted FEV1.

Conclusions:

  • Sleep quality in children with CF is influenced by lung health and co-morbidities.
  • Family characteristics and poor sleep hygiene (e.g., electronic device use) also contribute to sleep disturbance.
  • Optimizing CF management is key, but addressing specific factors like comorbidities and sleep hygiene offers additional targets for improving sleep in these children.
Abstract

Keywords:
ActigraphyOximetrySleepSleep hygiene

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