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Updated: Mar 2, 2026
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Isolation of Type I and Type II Pericytes from Mouse Skeletal Muscles
Published on: May 26, 2017
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Pericytes are heterogeneous in their origin within the same tissue.
Pedro Henrique Dias Moura Prazeres1, Isadora Fernandes Gilson Sena1, Isabella da Terra Borges1
1Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Developmental Biology
|May 9, 2017
Summary
Pericyte heterogeneity is more complex than previously thought. Some dermal pericytes originate from the hematopoietic lineage, revealing diverse embryonic origins for these crucial cells.
Area of Science:
- Developmental biology
- Cell biology
- Hematology
Background:
- Pericyte heterogeneity is recognized based on morphology, distribution, and markers.
- Distinct embryonic origins are known for pericytes in different organs.
Purpose of the Study:
- To investigate the heterogeneity of pericyte origins within the same tissue.
- To reveal unexpected sources of pericyte development.
Main Methods:
- Utilized transgenic mouse models.
- Employed cell-lineage tracing techniques.
Main Results:
- Demonstrated greater pericyte heterogeneity than previously appreciated.
- Identified a subpopulation of embryonic dermal pericytes originating from the hematopoietic lineage.
- Confirmed diverse embryonic origins for pericytes within a single tissue.
Conclusions:
- Pericyte lineage reconstruction is vital for understanding development.
- Understanding pericyte origins is crucial for diagnosing and treating related diseases.
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