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Updated: Mar 2, 2026

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research

Published on: August 16, 2017

Comparative transcriptomics in human and mouse.

Alessandra Breschi^1,2, Thomas R Gingeras³, Roderic Guigó^1,2

¹Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.

Nature Reviews. Genetics

|May 9, 2017

Summary

This summary is machine-generated.

Comparing human and mouse molecular biology reveals conserved gene expression and epigenetics. Emerging technologies address limitations, optimizing mouse models for human disease research.

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Area of Science:

Comparative genomics
Molecular biology
Translational research

Background:

High-throughput sequencing enables detailed cross-species molecular comparisons.
Human and mouse biology share significant molecular conservation.

Purpose of the Study:

To assess the conservation of human and mouse biology at the molecular level.
To identify limitations and opportunities for improving mouse models of human disease.

Main Methods:

Genome and transcriptome sequencing
Gene expression analysis
Epigenetic profiling
Analysis of inter-individual variation

Main Results:

Significant conservation observed in gene expression and epigenetics between humans and mice.
Identified limitations include incomplete transcriptome data and challenges in orthologous phenotype identification.

Conclusions:

Cross-species comparisons enhance understanding of conserved biological mechanisms.
Ongoing technological advancements are crucial for refining mouse models in human physiology and disease research.