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Updated: Mar 2, 2026

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

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Published on: August 11, 2023

Redefining epithelial characterization in oral submucous fibrosis using morphometric analysis.

Ajit Singh Rathore¹, Amit Gupta², Devi Charan Shetty¹

¹Department of Oral and Maxillofacial Pathology and Microbiology, ITS Centre for Dental Studies and Research, Ghaziabad, Uttar Pradesh, India.

Journal of Oral and Maxillofacial Pathology : JOMFP

|May 9, 2017

Summary

Oral submucous fibrosis (OSMF) leads to decreased epithelial thickness as the condition progresses. Morphometric analysis reveals a significant correlation between reduced epithelial thickness and altered cell morphology in OSMF patients.

Keywords:

Atrophy cell morphology morphometry oral submucous fibrosis

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Area of Science:

Oral pathology
Histopathology
Biomedical imaging

Background:

Oral submucous fibrosis (OSMF) is a chronic oral mucosal disease.
Characterized by collagen deposition and epithelial atrophy.
Affects subepithelial connective tissue.

Purpose of the Study:

Evaluate changes in epithelial thickness in OSMF.
Analyze cellular and nuclear morphometric characteristics.
Compare OSMF stages to normal epithelium.

Main Methods:

Morphometric analysis of epithelial thickness and cell morphology.
Utilized digital images and image analysis software.
Included 30 OSMF cases and 5 normal controls.

Main Results:

Statistically significant decrease in epithelial thickness with OSMF severity.
Highly significant correlation between epithelial thickness and cell morphology (P=0.000).

Conclusions:

Quantitative histological methods confirm epithelial atrophy in OSMF.
Epithelial thickness reduction correlates with increasing OSMF stages.
Changes may result from altered cell morphology within epithelial compartments.