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Published on: February 27, 2021
Biosynthesis, Characterization, and Biological Activities of Iron Nanoparticles using Sesamum indicum Seeds Extract
Farah Bano1, Muhammad Baber1, Amjad Ali2
1Institute of Molecular Biology and Biotechnology, Bahauddin Zakariya University, Multan, Pakistan.
Background:
Iron nanoparticles (FeNPs) have got many biomedical and health applications because of biocompatible and nontoxic nature to humans.
Objective:
To synthesize the FeNPs using natural sources.
Materials And Methods:
In this study, simple and economical procedure was adopted for FeNPs synthesis. Sesame seeds were processed to obtain seed extract as a biological material for FeNPs production. FeNPs were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopic.
Results:
The average diameter of these FeNPs was 99 nm. These nanoparticles showed significant anti-typhoid activity (30 mm zone of inhibition) as compared to ciprofloxacin (32 mm) as standard. Furthermore, in vitro alpha-amylase inhibitory assay also showed moderate antidiabetic activity with more than 50% inhibition.
Conclusion:
This study would be helpful in understanding of nanoparticles synthesis from natural sources and ultimately will be used as potential alternative therapeutic agents.
Summary:
Iron nanoparticles (FeNPs) were synthesized by Sesamum indicum seedsFeNPs were characterized by scanning electron microscope with average diameter of 99 nmThese FeNPs are effective against Salmonella typhi, a causative agent of typhoidThese FeNPs can be used as antidiabetic agent. Abbreviations used: FeNPs: Iron Nano Particles; SEM: Scanning Electron Microscopy; MIC: Minimum Inhibitory Concentration; S. indicum: Sesamum Indicum.
