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[Improved diagnosis using deuterated radiopharmaceuticals?--A comparison of the brain affinity of amphetamine
M Wenzl1, M Langstaedtler, D Preiss
1Pharmazeutisches Institut der Freien Universität Berlin, F.R.G.
International Journal of Radiation Applications and Instrumentation. Part A, Applied Radiation and Isotopes
|January 1, 1988
Abstract:
Ruthenocene amphetamine analogues have the same brain uptake as iodo-labelled amphetamines. This paper compares the organ-distribution of 103Ru labelled ruthenocene- or ferrocene-amphetamine analogues in mice and rats with the same amphetamine in which H-atoms were partly substituted by D-atoms. The uptake in the brain is increased up to 180-200% for deuterium substituted compounds. The pattern of excreted metabolites leads to the conclusion that the deuterated amphetamines are more slowly metabolised than normal (H) compounds.