Mapping the evolving definitions of translational research.

Area of Science:

• Biomedical Sciences
• Translational Science
• Health Services Research

Background:

• Definitions of translational research lack consensus.
• Understanding the phases of translational research is crucial for effective knowledge translation.

Purpose of the Study:

• To systematically review and analyze existing definitions of translational research.
• To identify commonalities and emerging consensus in translational research phases.

Main Methods:

• Systematic review of 33 papers on translational research definitions.
• Mapping definitions to common research processes.
• Citation analysis and agglomerative clustering to evaluate influence and group definitions.

Main Results:

• Definitions were mapped to common research processes, highlighting frequent labels.
• Agglomerative clustering identified 3 main families of definitions.
• Originating papers of definition families received significantly more citations.

Conclusions:

• An emerging consensus on a 5-phase model (T0-T4) for translational research was identified.
• The model outlines distinct research processes from basic science to population health.
• This consensus aids in standardizing the understanding and application of translational research principles.