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Pembrolizumab-induced pneumonitis.
Vincent Leroy1, Carole Templier2, Jean-Baptiste Faivre3
1Service de Pneumologie et Immuno-allergologie, Centre de Compétences des Maladies Pulmonaires Rares, CHU Lille, Lille, France.
ERJ Open Research
|May 9, 2017
Summary
Pembrolizumab can cause pneumonitis, a lung inflammation. Two of three described cases presented as organizing pneumonia, a specific type of lung injury.
Area of Science:
- Oncology
- Pulmonology
- Immunology
Background:
- Pembrolizumab is an immune checkpoint inhibitor used in cancer therapy.
- Immune-related adverse events (irAEs) are known side effects of pembrolizumab.
- Pneumonitis is a recognized irAE associated with immune checkpoint inhibitors.
Purpose of the Study:
- To describe clinical cases of pembrolizumab-induced pneumonitis.
- To highlight the specific presentation of organizing pneumonia in two cases.
Main Methods:
- Case report of three patients treated with pembrolizumab.
- Clinical and radiological review of the patients' lung conditions.
Main Results:
- Three patients developed pneumonitis during pembrolizumab therapy.
- Two of these cases exhibited histological and/or radiological features consistent with organizing pneumonia.
Conclusions:
- Pembrolizumab can induce pneumonitis.
- Organizing pneumonia is a potential manifestation of pembrolizumab-induced lung injury.
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