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Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking
07:21

Magnetic Resonance Derived Myocardial Strain Assessment Using Feature Tracking

Published on: February 12, 2011

14.9K

Distribution of strain patterns in children with dilated cardiomyopathy

Susanna L den Boer1, Gideon J du Marchie Sarvaas2, Liselotte M Klitsie3

  • 1Departments of Pediatrics, Division of Pediatric Cardiology, Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands.

Echocardiography (Mount Kisco, N.Y.)
|May 9, 2017
PubMed

Insights

Quantitative and qualitative dyssynchrony parameters assessed by two-dimensional speckle tracking echocardiography (STE) are not reproducible in children with dilated cardiomyopathy (DCM). Reduced strain, not dyssynchrony, was the main finding, suggesting dyssynchrony is a minor issue in pediatric DCM.

Area of Science:

  • Pediatric cardiology
  • Cardiovascular imaging
  • Echocardiography

Background:

  • Dyssynchrony parameters predict outcomes in adult heart failure.
  • Limited data exists on dyssynchrony in pediatric dilated cardiomyopathy (DCM).

Purpose of the Study:

  • Evaluate predictive value of quantitative and qualitative dyssynchrony parameters using STE in pediatric DCM.
  • Assess reproducibility of these STE-derived parameters in children.

Main Methods:

  • Prospective, multicenter study of 75 children with DCM and 75 controls.
  • Two-dimensional speckle tracking echocardiography (STE) assessed quantitative and qualitative dyssynchrony.
  • Cox regression identified risk factors for death or heart transplantation.

Main Results:

  • 13% of patients reached endpoint during 21-month follow-up.
  • Quantitative dyssynchrony measures were higher in DCM patients but had high variability.
  • Qualitative analysis revealed reduced strain, not dyssynchronous patterns.

Conclusions:

  • Quantitative dyssynchrony parameters lack reproducibility in children, limiting clinical use.
  • Qualitative analysis suggests reduced strain, not dyssynchrony, is characteristic of pediatric DCM.
  • Dyssynchrony appears to be a minor problem in children with DCM.
Abstract

Keywords:
dilated cardiomyopathymyocardial strain

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