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A single-shot T2 mapping protocol based on echo-split gradient-spin-echo acquisition and parametric multiplexed

Mei-Lan Chu1, Hing-Chiu Chang2, Koichi Oshio3

  • 1Brain Imaging and Analysis Center, Duke University Medical Center, Durham, North Carolina, USA.

Magnetic Resonance in Medicine
|May 9, 2017
PubMed
Summary
This summary is machine-generated.

This study introduces a fast T2 mapping technique using a novel echo-split gradient-spin-echo (GRASE) sequence. The method achieves accurate T2 measurements in under 0.2 seconds per slice, significantly reducing scan times.

Keywords:
GRASET2 mappingecho-split GRASEextended phase graph analysisparametric-POCSMUSE

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Area of Science:

  • Magnetic Resonance Imaging
  • Quantitative MRI

Background:

  • Developing rapid T2 mapping protocols is crucial for clinical applications.
  • Conventional methods often require long acquisition times or suffer from signal contamination.
  • Gradient-spin-echo (GRASE) sequences offer potential for faster data acquisition.

Purpose of the Study:

  • To develop a high-speed, single-shot T2 mapping protocol.
  • To accurately measure T2 relaxation time constants.
  • To minimize signal contamination from complex echo pathways.

Main Methods:

  • A novel echo-split single-shot GRASE pulse sequence was developed.
  • Parametric multiplexed sensitivity encoding based on projection onto convex sets (parametric-POCSMUSE) reconstruction was employed.
  • The protocol was evaluated in human studies at 3 Tesla and compared to a time-consuming interleaved spin-echo echo planar imaging protocol.

Main Results:

  • Quantitative T2 maps were successfully obtained using the developed single-shot protocol.
  • Scan times were significantly reduced to less than 0.2 seconds per slice.
  • The new method demonstrated accurate T2 measurements compared to reference protocols.

Conclusions:

  • The integrated approach of single-shot echo-split GRASE acquisition and parametric-POCSMUSE reconstruction enables accurate T2 mapping.
  • This method effectively minimizes signal contamination from Carr-Purcell-Meiboom-Gill (CPMG) high-order echo pathways.
  • The developed protocol offers a substantial improvement in speed for T2 mapping.