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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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Novel agents in mantle cell lymphoma

David Tucker1, Simon Rule2

  • 1a Department of Haematology , Derriford Hospital , Plymouth , UK.

Expert Review of Anticancer Therapy
|May 9, 2017
PubMed
Abstract

Insights

Novel targeted therapies have transformed mantle cell lymphoma (MCL) treatment, offering new hope for patients with this aggressive cancer. Research highlights licensed and emerging agents, including Bruton

Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma with a historically poor prognosis.
  • Recent advancements in targeted therapies have significantly improved treatment options for MCL.
  • Novel agents target specific intracellular pathways and the tumor microenvironment.

Purpose of the Study:

  • To summarize licensed novel agents for front-line and relapsed/refractory MCL treatment.
  • To discuss promising targeted therapies in earlier stages of development.
  • To provide an expert commentary on the evolving landscape of MCL therapeutics.

Main Methods:

  • Literature search using terms like 'mantle cell lymphoma', 'bortezomib', 'ibrutinib', and 'targeted molecular therapies'.
  • Review of current literature on licensed and investigational agents for MCL.
  • Synthesis of findings to provide an expert perspective.

Main Results:

  • Novel molecular targets and drugs have revolutionized MCL therapy beyond traditional immunochemotherapy.
  • Targeted agents, including Bruton's tyrosine kinase inhibitors, represent a significant breakthrough.
  • Several novel agents are now licensed for MCL treatment in various settings.

Conclusions:

  • Targeted therapies have transformed MCL treatment, improving outcomes for patients.
  • Optimizing the sequencing and combination of these agents presents new challenges.
  • Overcoming drug resistance is a critical area for future research in MCL.
Keywords:
Mantlebortezomibibrutiniblenalidomidelymphomanoveltemsirolimustherapies

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