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Injectable dual redox responsive diselenide-containing poly(ethylene glycol) hydrogel
Chu Gong1, Meng Shan1, Bingqiang Li1
1Key Laboratory of Functional Polymer Materials, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin, 300071, People's Republic of China.
Journal of Biomedical Materials Research. Part A
|May 9, 2017
Summary
Researchers developed an injectable dual redox-responsive poly(ethylene glycol) (PEG) hydrogel using diselenide crosslinkers. This novel hydrogel demonstrates controlled drug release, showing promise for advanced drug delivery systems.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Drug Delivery Systems
Background:
- Injectable hydrogels offer minimally invasive administration routes.
- Redox-responsive materials can degrade or release payloads in response to specific biological environments.
- Diselenide bonds provide tunable redox-responsive properties.
Purpose of the Study:
- To develop an injectable hydrogel system with dual redox responsiveness.
- To investigate the synthesis and characterization of diselenide-containing PEG hydrogels.
- To evaluate the drug release profile and degradation behavior of the developed hydrogel.
Main Methods:
- Synthesis of four-armed PEG with NHS-activated esters.
- Crosslinking of PEG chains using selenocystamine to form hydrogels.
- Characterization using SEM, rheological measurements, and FTIR.
- In vitro degradation studies and drug release experiments with rhodamine B.
Main Results:
- Successful formation of injectable, dual redox-responsive diselenide-containing PEG hydrogels.
- Hydrogels exhibited tunable mechanical properties and crosslinking modes.
- Demonstrated oxidation- and reduction-responsive degradation.
- Drug-loaded hydrogel showed a dual redox-responsive release profile.
Conclusions:
- The developed injectable hydrogel system possesses dual redox-responsive properties.
- The hydrogel is suitable for controlled and stimuli-responsive drug release.
- Potential applications in various biomedical fields, including drug delivery, are indicated.
