Related Experiment Video
Updated: Mar 2, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Preparation and evaluation of a novel bonded imidazolium ionic liquid as stationary phase for gas chromatography
Jia-Ling Dai1, Li-Hua Zhao1, Jie-Hua Shi1,2
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, China.
Abstract:
1-Butyl-3-[(3-trimethoxysilyl)propyl]imidazolium chloride ionic liquid was synthesized and chemically modified onto the inner wall of a fused capillary column as a stationary phase for gas chromatography. The 1-butyl-3-[(3-trimethoxysilyl)propyl]imidazolium chloride ionic liquid bonded capillary column was evaluated in detail. The results revealed that the ionic liquid bonded capillary column exhibited high column efficiency of 1.08 × 104 plates/m, and good chromatographic separation selectivity (α) for polar and non-polar substances, and a good thermal stability between room temperature and 400°C. Moreover, the determination of thermodynamic parameters and the linear solvation energy relationship were further carried out. The results indicated that the chromatographic retention of each probe molecule on the ionic liquid bonded stationary phase was an enthalpy-driven process, and the system constants of the linear solvation energy relationship signified that the dispersion interaction, the hydrogen bonding acidity and hydrogen bonding basicity were dominant interactions between probes and stationary phase among five interactions during the chromatographic separation. However, the contribution of each specific interaction for the stationary phase is ranked as the dispersion interaction > the hydrogen bonding basicity > the hydrogen bonding acidity.
More Related Videos
Related Concept Videos
Gas Chromatography: Types of Columns and Stationary Phases
For an analyte to remain on the column for a sufficient amount of time, it must exhibit some level of compatibility (or...
Gas Chromatography: Introduction
In GC, a sample is vaporized and mixed with an inert carrier gas (the mobile phase), which transports it through a...
High-Performance Liquid Chromatography: Introduction
In HPLC, two phases play a critical role in the separation process:
High-Performance Liquid Chromatography: Elution Process
Silica Gel Column Chromatography: Overview
Polar components tend to bind strongly to the silica gel, causing them to move slowly through the column. In contrast, nonpolar compounds...
Ion-Exchange Chromatography

