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Instant Hydrogelation Inspired by Inflammasomes.

Huaimin Wang1, Zhaoqianqi Feng1, Alvin Lu2

  • 1Department of chemistry, Brandeis University, 415 South St, Waltham, MA, 02454, USA.

Angewandte Chemie (International Ed. in English)
|May 9, 2017
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Summary

Researchers designed a peptide that self-assembles into nanofibers. This peptide rapidly forms hydrogels when mixed with vitamin B6 (pyridoxal phosphate) or other small molecules, demonstrating a bioinspired approach to supramolecular assembly.

Keywords:
hydrogelspeptidesself-assemblyvitamin B6wound healing

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Area of Science:

  • Biomaterials Science
  • Supramolecular Chemistry
  • Inflammasome Biology

Background:

  • Recent near-atomic structures reveal the inflammasome's ASC protein filament assembly.
  • The active form of vitamin B6, pyridoxal phosphate (P5P), influences ASC self-assembly.
  • Understanding these interactions can inspire novel biomaterials.

Purpose of the Study:

  • To rationally design a peptide capable of forming self-assembled supramolecular nanofibers.
  • To investigate the modulation of peptide self-assembly by endogenous small molecules.
  • To demonstrate a bioinspired approach for creating responsive hydrogels.

Main Methods:

  • Design and synthesis of an N-terminal capped nonapeptide (Nap-FFKKFKLKL).
  • Characterization of peptide self-assembly into α-helix nanofibers.
  • Induction of hydrogel formation using P5P and other small molecules.

Main Results:

  • The designed nonapeptide self-assembles into stable α-helix nanofibers.
  • Addition of P5P to the peptide solution resulted in rapid hydrogel formation (approx. 4 seconds).
  • Other endogenous small molecules, including pyridoxal, folinic acid, ATP, and AMP, also induced hydrogelation.

Conclusions:

  • The study successfully designed a peptide that forms supramolecular nanofibers.
  • Endogenous small molecules, notably P5P, can effectively modulate peptide self-assembly into hydrogels.
  • This work presents a bioinspired strategy for developing small molecule-responsive supramolecular materials.