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Related Experiment Video

Updated: Mar 2, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

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Two hearts synchronized each other with a DDD pacemaker.

Michele Brunacci¹, Alberto Valbusa, Claudio Brunelli

¹IRRCS San Martino, Largo Rosanna Benzi, Genoa, Italy.

Journal of Cardiovascular Medicine (Hagerstown, Md.)

|May 9, 2017

Summary

A patient with two hearts experienced ventricular fibrillation from the native heart, but the transplanted heart maintained sinus rhythm. Pacemaker synchronization and cardioversion successfully managed symptoms.

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Area of Science:

Cardiology
Cardiac Electrophysiology
Transplant Surgery

Background:

Heterotopic cardiac transplantation involves implanting a donor heart alongside the patient's native heart.
Managing patients with dual cardiac rhythms presents unique electrophysiological challenges.

Observation:

A patient presented with dyspnea, exhibiting ventricular fibrillation in the native heart and sinus rhythm in the transplanted heart.
The native and transplanted hearts required synchronization using a pacemaker.

Findings:

Successful electrical external cardioversion was performed.
Alternative pacemaker stimulation strategies were employed effectively.
Patient symptoms significantly improved following interventions.

Implications:

This case highlights the feasibility of managing complex arrhythmias in heterotopic heart transplant recipients.
Effective pacemaker management and cardioversion can restore hemodynamic stability.
Further research into dual-heart synchronization techniques is warranted.