Related Experiment Video

Updated: Mar 2, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
03:45

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model

Published on: August 8, 2022

4.3K

Genomics of Cardiometabolic Disorders in Sub-Saharan Africa

Sally N Adebamowo1, Fasil Tekola-Ayele, Adebowale A Adeyemo

  • 1Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, MD, USA.

Public Health Genomics
|May 9, 2017
PubMed

Insights

Cardiometabolic disorders are rising in Sub-Saharan Africa due to lifestyle changes and genetics. More genomic research is needed to understand individual susceptibility and guide public health strategies.

Area of Science:

  • Genomics
  • Public Health
  • Cardiology

Background:

  • Sub-Saharan Africa faces a growing burden of cardiometabolic disorders like diabetes and hypertension.
  • These conditions are driven by complex environmental and genetic factors, with genetic influences on susceptibility largely unknown.
  • Economic progress and demographic shifts are accelerating these disease trends.

Purpose of the Study:

  • To summarize current knowledge on the genomics of cardiometabolic disorders in Sub-Saharan Africa.
  • To identify research gaps and opportunities in this field.
  • To inform future genetic research and public health initiatives.

Main Methods:

  • Review of recent literature on cardiometabolic disorder genomics in Sub-Saharan Africa.
  • Analysis of genetic diversity studies in the region.
  • Identification of research challenges and future directions.

Main Results:

  • Genomic studies in Sub-Saharan Africa have lagged behind other populations.
  • Understanding genetic factors is crucial for personalized susceptibility prediction.
  • Significant research opportunities exist for characterizing genetic diversity and its role in disease.

Conclusions:

  • Urgent need for increased genomic research on cardiometabolic disorders in Sub-Saharan Africa.
  • Genomic insights can improve disease prevention and management strategies.
  • Collaborative research efforts are essential to address the growing health challenge.

Keywords:
AfricaCardiometabolic disordersCoronary heart diseaseDiabetesDyslipidemiaGenomicsHypertensionObesityStroke

More Related Videos

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.9K
Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System07:34

Fetal Mouse Cardiovascular Imaging Using a High-frequency Ultrasound 30/45MHZ System

Published on: May 5, 2018

12.4K

Related Concept Videos

Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
53
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
16.0K
Principles of Pharmacogenetics: Types of Genetic Variants01:27

Principles of Pharmacogenetics: Types of Genetic Variants

The human genome is over 99.9% identical between individuals, yet genetic differences exist at millions of bases. The human genome contains approximately 3 million variant positions per individual, many of which are heterozygous, contributing to genetic diversity and individual traits. Genetic variations include single-nucleotide polymorphisms (SNPs), insertions, deletions, and copy number variations (CNVs).SNPs, the most common variation, involve single-base changes in DNA. These can be...
60
Human Genetics01:28

Human Genetics

Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.8K
Incomplete Dominance01:43

Incomplete Dominance

Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
30.7K
Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.7K