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ADHD treatment and diagnosis in relation to children's birth month: Nationwide cohort study from Norway
Øystein Karlstad1, Kari Furu1, Camilla Stoltenberg1,2
11 Norwegian Institute of Public Health, Oslo, Norway.
Insights
Children born later in the year, making them youngest in their class, have a higher risk of attention-deficit/hyperactivity disorder (ADHD) diagnosis and treatment. This risk increases with age, particularly in older students.
Area of Science:
- Pediatric medicine
- Neurodevelopmental disorders
- Public health
Background:
- Studies indicate a link between being the youngest in a grade and increased risk for attention-deficit/hyperactivity disorder (ADHD) diagnosis and treatment.
- In Norway, children born in December are the youngest in their school grade, as school entry is at age six.
- This study investigates the association between birth month and ADHD in a large Norwegian cohort.
Purpose of the Study:
- To examine the association between birth month and the risk of attention-deficit/hyperactivity disorder (ADHD) diagnosis and medication.
- To assess if the risk of ADHD diagnosis and treatment varies based on a child's birth month and grade level.
Main Methods:
- Utilized national registers for medication, specialist, and primary healthcare diagnoses for 509,827 children born in Norway (1998-2006).
- Employed Cox proportional-hazards models to estimate hazard ratios for ADHD by birth month, controlling for socioeconomic factors using sibling analyses.
- Conducted cross-sectional time-series analyses to evaluate ADHD medication risk by birth month across different school grades.
Main Results:
- Children born in October-December had a higher prevalence of ADHD medication compared to those born in January-March (Boys: 5.3% vs 3.7%; Girls: 2.2% vs 1.3%).
- Adjusted hazard ratios for ADHD medication were elevated for children born in late autumn (Boys: 1.4; Girls: 1.8) compared to early spring.
- Increased risk for ADHD diagnosis and treatment was observed for children born late in the year from grade 3 onwards, with greater disparities in higher grades.
Conclusions:
- Being the youngest child in a grade is associated with a higher risk of receiving attention-deficit/hyperactivity disorder (ADHD) treatment.
- The disparity in ADHD treatment risk based on birth month becomes more pronounced in older children.
- Findings highlight the impact of relative age within a school cohort on ADHD diagnosis and treatment patterns.
Background:
Studies from several countries have reported that children youngest in grade are at higher risk of attention-deficit/hyperactivity disorder (ADHD) diagnosis and treatment. Norwegian children start school the year they turn six, making children born in December youngest in their grade. We used data on medication, specialist healthcare diagnoses, and primary healthcare diagnoses from national registers to investigate associations between birth month and ADHD.
Methods:
All children born in Norway between 1998 and 2006 ( N=509,827) were followed from age six until 31 December 2014. We estimated hazard ratios for ADHD medication and diagnoses by birth month in Cox proportional-hazards models. We compared risk among siblings to control for potentially confounding socioeconomic factors, and assessed risk of receiving ADHD medication by birth month while attending different grades in cross-sectional time-series analyses.
Results:
At end of follow-up, 5.3% of boys born in October-December had received ADHD medication, compared with 3.7% of boys born in January-March. Corresponding numbers for girls were 2.2% and 1.3%, respectively. The adjusted hazard ratio for ADHD medication for children born in October-December (reference: January-March) was 1.4 (95% confidence interval: 1.4-1.5) for boys and 1.8 (1.7-2.0) for girls. Analyses with diagnoses as outcome showed consistent results, and analyses restricted to siblings within the study population also supported the findings. Analysis by grade revealed an increased risk for children born late in the year from grade 3 onwards, with most marked differences in higher grades.
Conclusions:
Children youngest in grade had the highest risk of receiving ADHD treatment. Differences were most marked among older children.
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