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Ophthalmic Drug Delivery Systems

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

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Updated: Mar 2, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

Recent Advancemnts in Biodegradable Ocular Implants.

Swati Mittal¹, Oshin Miranda²

¹Department of Pharmaceutics, Vivekanand Education Society's College of Pharmacy, Chembur, Mumbai-4000074, India.

Current Drug Delivery

|May 10, 2017

Summary

Biodegradable ocular drug delivery systems offer improved vision quality and patient compliance compared to traditional methods. This review highlights advancements in biodegradable systems for enhanced ocular drug delivery.

Keywords:

Biodegradable polymers advancements bioavailability.biodegradable implants ocular implants pharmaceutical technology

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Last Updated: Mar 2, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

Customizing a Cryolite Glass Prosthetic Eye

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Published on: October 31, 2019

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

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Published on: September 12, 2014

Area of Science:

Ophthalmology and Pharmaceutical Sciences
Biomaterials and Drug Delivery Systems

Background:

Maintaining healthy vision is crucial for individual well-being.
Conventional systemic ocular drug therapies suffer from low bioavailability, side effects, and poor patient compliance.
Ocular drug delivery systems aim to optimize bioavailability and patient adherence.

Purpose of the Study:

To review the current progress in the formulation and optimization of biodegradable ocular drug delivery systems.
To discuss the characteristics of these advanced biodegradable systems.

Main Methods:

Literature review of biodegradable ocular drug delivery systems.
Analysis of formulation strategies and optimization techniques.
Evaluation of system characteristics and benefits.

Main Results:

Biodegradable ocular implants represent a significant advancement over non-biodegradable systems.
These systems offer enhanced drug bioavailability and prolonged therapeutic effects.
Improved patient compliance is a key advantage of biodegradable ocular drug delivery.

Conclusions:

Biodegradable ocular drug delivery systems show great promise for improving vision health.
Continued research in formulation and optimization will further enhance their efficacy.
These systems represent a key area of innovation in ophthalmic therapeutics.