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Mechanisms Regulating PRC2 Recruitment and Enzymatic Activity

Daniel Holoch1, Raphaël Margueron1

  • 1Institut Curie, Paris Sciences et Lettres (PSL) Research University, 26 rue d'Ulm, 75248 Paris, France; Génétique et Biologie du Développement, Institut National de la Santé et de la Recherche Médicale (INSERM) Unité U934, Centre National de la Recherche Scientifique (CNRS) Unité Mixte de Recherche 3215, Institut Curie, 26 rue d'Ulm, 75248 Paris, France.

Trends in Biochemical Sciences
|May 10, 2017
PubMed

Insights

Polycomb repressive complex 2 (PRC2) is vital for development by controlling gene expression. New research reveals complex regulatory mechanisms involving PRC2 subunits and chromatin, advancing our understanding of its function.

Area of Science:

  • Epigenetics and Gene Regulation
  • Molecular Biology
  • Developmental Biology

Background:

  • Polycomb repressive complex 2 (PRC2) plays a critical role in multicellular development.
  • PRC2 establishes transcriptional repression patterns through histone H3 lysine-27 methylation.
  • Understanding PRC2 regulation is key to deciphering developmental processes.

Purpose of the Study:

  • To summarize recent advances in understanding the intricate mechanisms regulating PRC2.
  • To highlight the roles of facultative PRC2 subunits, PRC1, and chromatin in PRC2 function.
  • To identify emerging questions in the field of PRC2 regulation.

Main Methods:

  • Review of recent molecular and biochemical studies on PRC2.
  • Analysis of findings on PRC2 recruitment and enzymatic activity.
  • Integration of data on chromatin environment interactions.

Main Results:

  • PRC2 activity is finely tuned by multiple regulatory inputs.
  • Facultative PRC2 subunits and PRC1 significantly influence PRC2 function.
  • Chromatin features provide specific contexts for PRC2 action.

Conclusions:

  • The regulation of PRC2 is complex and multifaceted.
  • Recent discoveries offer a dynamic view of biochemical signals governing PRC2.
  • Further research is needed to fully elucidate remaining questions on PRC2 function.
Keywords:
H3K27me3PRC1PRC2PRC2 facultative subunitsPRC2 regulationtranscriptional repression

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