[Acid-stable and acid-labile interferons inducible by the bovine infectious rhinotracheitis virus]

Attenuated and virulent strains of cattle infectious rhinotracheitis virus (IRTV) induced in cattle leukocytes the production of both acid-stable and acid-labile interferon. The attenuated IRTV strain induced the production of the acid-labile interferon in spleen and bone marrow cells of BALB/C mice. The indication of the assignment of the acid-labile interferon to the leukocyte-type of interferon consists in the activity of bovine interferon in a heterologous culture of human diploid fibroblasts and a higher interferon titer in bone marrow than in spleen cells (bone marrow cells contain B-cells which produce leukocyte interferon).