Effects of Propranolol and Verapamil on Changes in TQ and ST Segment Potentials During Graded Coronary Flow Reduction...

Acute myocardial ischemia causes TQ depression and ST elevation. However, the effects of cardioprotective drugs such as β-blockers and Ca⁺⁺-antagonists on the extent of TQ depression, ST elevation, and myocardial ischemic injury are not fully understood.We created a carotid-coronary shunt in 30 pigs, and extracellular K⁺ ([K⁺]_e), TQ, and ST segments were recorded simultaneously with K⁺-selective plunge electrodes placed in the left anterior descending artery (LAD) distribution during graded LAD flow reduction before and after administration of propranolol or verapamil. Unipolar DC-coupled electrograms were recorded from the reference pole of the K⁺-selective plunge electrodes. The microvolt readings from the K⁺-selective electrodes were converted to [K⁺]_e and then to the changes in potassium equilibrium potential (ΔE_K). The shunted LAD flow was reduced in a stepwise fashion at 5-minute intervals.segment depression at the similar ΔE_K was not affected by propranolol or verapamil. However, ST segment elevation was reduced by propranolol but exacerbated by verapamil at the similar ΔE_K.TQ-ST changes recorded by AC coupled ECG are not a reliable index of ischemia and therefore cannot be used to evaluate the effects of drugs that might affect the electrophysiologic properties of ischemic myocardium.