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Systemic mastocytosis associated with membranous nephropathy and peripheral neuropathy
S M Lal1, C S Brooks, A M Luger
1Department of Medicine, University of Missouri Health Sciences Center, Columbia 65212.
Abstract:
A report of the occurrence of membranous nephropathy and peripheral neuropathy in a patient with systemic mastocytosis is presented. Previous reviews of patients with systemic mastocytosis have not noted this association. During cyclical therapy with prednisone and chlorambucil in this case, nephrotic-range proteinuria remitted. Peripheral neuropathy resolved 10 months after discontinuation of therapy. Pathophysiological mechanisms resulting in this clinical presentation may be immunologically mediated.