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Related Experiment Video

Updated: Mar 2, 2026

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
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Clival defect causing primary spontaneous rhinorrhea.

Vivek Tandon1, Kanwaljeet Garg1, Ashish Suri1

  • 1Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Asian Journal of Neurosurgery
|May 10, 2017
PubMed
Summary
This summary is machine-generated.

This study reports a rare case of cerebrospinal fluid (CSF) rhinorrhea caused by a clival defect. Surgical repair using neuronavigation successfully treated the recurrent CSF leak and meningitis.

Keywords:
Cerebrospinal fluidclivusrhinorrheaspontaneous

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Area of Science:

  • Neurosurgery
  • Otolaryngology
  • Neurology

Background:

  • Primary cerebrospinal fluid (CSF) rhinorrhea originating from a clival defect is exceptionally rare, with only four prior documented cases.
  • Spontaneous CSF leaks can lead to serious complications such as meningitis.

Observation:

  • A 55-year-old female presented with recurrent spontaneous CSF rhinorrhea and a history of meningitis.
  • Previous endonasal surgery had been performed 9 years prior for the initial CSF leak.
  • Imaging revealed a clival defect as the source of the persistent CSF leak.

Findings:

  • A transsphenoidal surgical approach, guided by neuronavigation, was employed for the repair of the clival defect.
  • The recurrent CSF leak and associated meningitis were successfully managed with this surgical intervention.

Implications:

  • This case highlights the importance of considering clival defects in recurrent or complex CSF rhinorrhea cases.
  • Neuronavigation can enhance the precision and success of transsphenoidal repairs for challenging skull base defects.
  • Understanding fistula formation mechanisms is crucial for optimizing treatment strategies in rare CSF leak etiologies.