Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

2.9K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
2.9K
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

2.7K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
2.7K
Development of Immunocompetence01:22

Development of Immunocompetence

1.0K
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
1.0K
Immunological Memory01:23

Immunological Memory

17.5K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
17.5K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

7.7K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.7K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

85.2K
Overview
85.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Development of a Humanized Anti-Fibrotic Antibody Targeting Extracellular Collagen Assembly to Reduce Post-Traumatic Scarring.

bioRxiv : the preprint server for biology·2026
Same author

Simulated Workflow Feasibility Evaluation of a Web-Based Periorbital Measurement Platform: Development and Usability Study.

JMIR human factors·2026
Same author

Alternate splicing converts human CD137 from costimulatory to immunosuppressive function.

Journal of autoimmunity·2025
Same author

Seroprevalence of dengue virus infection among febrile patients visiting healthcare facilities in the selected districts of Afar region, Northeast Ethiopia.

BMC infectious diseases·2025
Same author

Higher order receptor clustering due to the IgG3 subclass is necessary for TLR4 signaling and tolerance induction by novel human anti-TLR4 antibodies.

mAbs·2025
Same author

Neutralization of Marinobufagenin Demonstrates Efficacy In Vitro and In Vivo in Models of Pre-Eclampsia.

Biomedicines·2025

Related Experiment Video

Updated: Mar 2, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

35.6K

Interleukin-7 and Immunosenescence.

Vanloan Nguyen1, Andrew Mendelsohn1, James W Larrick1

  • 1Panorama Research Institute, 1230 Bordeaux Drive, Sunnyvale, CA 94089, USA.

Journal of Immunology Research
|May 10, 2017
PubMed
Summary

Aging increases disease risk, but Interleukin-7 (IL-7) is crucial for immune system balance and healthspan. Understanding IL-7

Area of Science:

  • Immunology
  • Gerontology
  • Molecular Biology

Background:

  • Age is a primary risk factor for numerous prevalent diseases.
  • Interleukin-7 (IL-7) is vital for immune system homeostasis.
  • IL-7 is increasingly recognized for its role in maintaining a healthy lifespan.

Purpose of the Study:

  • To elucidate the function of IL-7 and its receptor in immunosenescence.
  • To explore the implications of IL-7 in the aging immune system.
  • To identify potential therapeutic avenues for age-related conditions.

Main Methods:

  • Review of existing literature on IL-7 and immunosenescence.
  • Analysis of the molecular mechanisms of IL-7 signaling in aging.
  • Correlation of IL-7 levels with immune system aging markers.

More Related Videos

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

9.3K
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.5K

Related Experiment Videos

Last Updated: Mar 2, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
12:59

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

35.6K
Visualization of IL-22-expressing Lymphocytes Using Reporter Mice
10:30

Visualization of IL-22-expressing Lymphocytes Using Reporter Mice

Published on: January 25, 2017

9.3K
Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood
07:58

Quantitative Imaging of Lineage-specific Toll-like Receptor-mediated Signaling in Monocytes and Dendritic Cells from Small Samples of Human Blood

Published on: April 16, 2012

35.5K

Main Results:

  • IL-7 plays a critical role in regulating immune system aging.
  • Dysregulation of IL-7 signaling contributes to immunosenescence.
  • IL-7 levels and receptor function are altered during the aging process.

Conclusions:

  • Targeting IL-7 may offer strategies to combat age-related immune decline.
  • Optimizing IL-7 function could enhance healthspan and longevity.
  • Further research into IL-7 pathways is warranted for preventative and therapeutic applications.