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Updated: Mar 2, 2026
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Vessel-sparing Excision and Primary Anastomosis
Published on: January 7, 2019
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[Long-term prognosis of Peters anomaly]
S Reichl1, D Böhringer2, O Richter2
1Klinik für Augenheilkunde, Universitätsklinikum Freiburg, Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg, Killianstr. 5, 79106, Freiburg, Deutschland. sabine.reichl@uniklinik-freiburg.de.
Summary
Peters anomaly, a childhood eye condition, has a poor visual prognosis despite surgical interventions. Early referral to visually impaired services is recommended due to high complication risks and limited long-term vision restoration.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Genetics
Background:
- Peters anomaly typically presents in early childhood with central corneal opacities and anterior eye segment dysgenesis.
- Early surgical intervention is often necessary for Peters anomaly to prevent severe amblyopia or manage glaucoma.
Purpose of the Study:
- To evaluate the clinical outcomes of patients with Peters anomaly treated since 2005.
- To emphasize the outcomes based on Peters anomaly subtypes.
Main Methods:
- Retrospective chart review of 23 patients diagnosed with Peters anomaly.
- Kaplan-Meier analysis to assess visual prognosis, keratoplasty indications, and retinal detachment incidence.
Main Results:
- Peters anomaly subtypes: 40% type 1, 50% type 2, 10% Peters plus syndrome.
- High rates of surgical intervention: 40.5% keratoplasty, 43% glaucoma surgery.
- Significant complications: 31% retinal detachment, 15% phthisis bulbi; poor visual acuity (≤0.05) in 50% after 4 years.
Conclusions:
- Peters anomaly has a generally poor visual prognosis with limited long-term functional vision restoration.
- Surgical interventions for Peters anomaly carry a high risk of severe complications.
- Early connection to visually impaired services is crucial for affected children.
