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Inclusion-body hepatitis in day-old turkeys.

J S Guy1, J L Schaeffer, H J Barnes

  • 1Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.

Avian Diseases
|July 1, 1988
PubMed
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Inclusion-body hepatitis caused by avian adenovirus led to high mortality in young turkeys. The study identified large intranuclear inclusion bodies in liver cells, confirming the diagnosis.

Area of Science:

  • Veterinary Pathology
  • Virology
  • Poultry Diseases

Background:

  • Inclusion-body hepatitis (IBH) is a significant disease in poultry.
  • High mortality events in commercial turkey flocks warrant investigation.

Observation:

  • A flock of 1-day-old turkeys exhibited elevated mortality rates.
  • Necropsy revealed anemia and pale yellow livers in affected poults.
  • Histopathology showed diffuse hepatic degeneration, multifocal necrosis, and characteristic intranuclear inclusion bodies in hepatocytes.

Findings:

  • A Group I avian adenovirus was successfully isolated from affected turkey livers.
  • The presence of basophilic intranuclear inclusion bodies in approximately 70% of hepatocytes confirmed IBH.

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Implications:

  • This finding highlights the etiological role of avian adenovirus in inclusion-body hepatitis in turkeys.
  • Understanding the viral cause is crucial for developing effective prevention and control strategies in poultry farming.
  • Further research into the specific adenovirus strain and its pathogenicity is recommended.