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Inclusion-body hepatitis in day-old turkeys
J S Guy1, J L Schaeffer, H J Barnes
1Department of Microbiology, Pathology, and Parasitology, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
Avian Diseases
|July 1, 1988
Summary
Inclusion-body hepatitis caused by avian adenovirus led to high mortality in young turkeys. The study identified large intranuclear inclusion bodies in liver cells, confirming the diagnosis.
Area of Science:
- Veterinary Pathology
- Virology
- Poultry Diseases
Background:
- Inclusion-body hepatitis (IBH) is a significant disease in poultry.
- High mortality events in commercial turkey flocks warrant investigation.
Observation:
- A flock of 1-day-old turkeys exhibited elevated mortality rates.
- Necropsy revealed anemia and pale yellow livers in affected poults.
- Histopathology showed diffuse hepatic degeneration, multifocal necrosis, and characteristic intranuclear inclusion bodies in hepatocytes.
Findings:
- A Group I avian adenovirus was successfully isolated from affected turkey livers.
- The presence of basophilic intranuclear inclusion bodies in approximately 70% of hepatocytes confirmed IBH.
Implications:
- This finding highlights the etiological role of avian adenovirus in inclusion-body hepatitis in turkeys.
- Understanding the viral cause is crucial for developing effective prevention and control strategies in poultry farming.
- Further research into the specific adenovirus strain and its pathogenicity is recommended.