Construction of Spirooxindole Skeleton Through Intramolecular Dieckmann Cyclization
Ting Wu1, Zhiqiang Pan2, Chengfeng Xia3
1The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang, 55002, China.
Abstract:
A highly efficient and direct approach was developed to construct the structurally diverse spirooxindole skeleton, which is an important basic motif in natural products. Both the 3,3'-pyrrolidonyl spirooxindoles and spiroindolin-2-one δ-lactones were smoothly obtained by the intramolecular Dieckmann cyclization of oxindoles in excellent yield under mild conditions.
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