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Brain microsomal oxidation of delta 8- and delta 9-tetrahydrocannabinol
K Watanabe1, T Tanaka, I Yamamoto
1Department of Hygienic Chemistry, School of Pharmacy, Hokuriku University, Kanazawa, Japan.
Biochemical and Biophysical Research Communications
|November 30, 1988
Abstract:
Brain microsomes of mice, rats, guinea pigs and rabbits catalyzed the oxidation of delta 8- and delta 9-tetrahydrocannabinol to their monohydroxylated metabolites. The most prominent metabolite was the 4'-hydroxylated metabolite on the pentyl side chain of the cannabinoids in all species tested, except that the 5'-hydroxylation of delta 9-tetrahydrocannabinol was most abundant in the guinea pig. These results are quite different from the metabolic profile of the cannabinoids with hepatic microsomes.